Several reports showed that increased expression of RCAN1.4 is associated with angiogenesis in hypopharyngeal cancer and Kaposi’s Sarcoma (KS) caused by Kaposi’s Sarcoma Herpesvirus (KSHV) [93-94], suggesting that increased RCAN1 expression may only be responsible for the inverse association of AD and some types but not all types of cancer. This evidence concerns the gene RCAN1 and Kaposi's sarcoma.