On the other hand, reduced RCAN1 promotes cancer development by attenuating cancer cell apoptosis, facilitating angiogenesis and promoting cancer cell proliferation, while it inhibits AD pathogenesis by attenuating neuronal apoptosis, facilitating angiogenesis and promoting neurogenesis via calcineurin-dependent or –independent pathways (Fig. 1). The gene discussed is RCAN1; the disease is Alzheimer disease.