RCAN1 and breast carcinoma: In addition, NFAT family members, downstream targets of RCAN1, are constitutively activated in several types of cancer, including breast cancer, pancreatic cancer, aggressive T cell lymphoma, Burkitt’s lymphoma, and diffuse large B cell lymphoma, suggesting that the inhibitory effect of RCAN1 on calcineurin/NFAT may be reduced by its downregulation [92].