RCAN1 and cancer: Several reports showed that increased expression of RCAN1.4 is associated with angiogenesis in hypopharyngeal cancer and Kaposi’s Sarcoma (KS) caused by Kaposi’s Sarcoma Herpesvirus (KSHV) [93-94], suggesting that increased RCAN1 expression may only be responsible for the inverse association of AD and some types but not all types of cancer.