PKP4 and heart failure: The deleted region on chromosome 2 in our patient harbors two genes: CCDC148 and PKP4. PKP4 has been speculated to be a modifier gene for LMNA in which a splicing mutation caused sudden death, ventricular arrhythmia, cardiomyopathy, and heart failure in a 63-year-old male with a family history of individuals (>10) with similar problems [47].