Consistent with previous report (20), the main source of IFNγ in this innate model of acute intestinal inflammation was mostly likely to be derived from group 3 innate lymphoid cells (ILC3) since targeting ILC3 responses by means of antibody depletion (anti-Thy1.2) or employing genetic models that lack ILC3 (Rag2−/−RorcGFP/GFP) ameliorated colitis (Figures 1A–C). The gene discussed is IFNG; the disease is colitis.