In line with this idea, using a T cell independent model of colitis, we showed that mice were fully protected from colitis in the absence of IFNγ (Rag1−/−Ifnγ−/− mice) or in the absence of ILC (anti-Thy1.2 depleted Rag1−/− mice or Rag2−/−RorcGFP/GFP mice), in agreement with previous studies (20, 39). This evidence concerns the gene RAG1 and colitis.