Several similarities exist between the LIP-driven autoimmunity described herein and certain clinical syndromes, such as immune reconstitution inflammatory syndrome (IRIS) in HIV patients experiencing a rebound of the CD4 T cell compartment after treatment with antiviral drugs (44, 63) or in chronic GVHD post-allogeneic bone marrow transplantation (64). The gene discussed is CD4; the disease is chronic graft versus host disease.