Indeed, splenocytes + lymph node cells from the diseased Prf1−/−PD-1−/− thymocyte recipients generated robust development of autoimmunity when transferred either to Rag−/− or Faslpr × Rag−/− recipients (disease onset: day 18, 22, >22 vs. 13, 18 × 3, 22, respectively; p = NS). The gene discussed is PRF1; the disease is Autoimmunity.