These contradictory results may also be explained by the duration of the HFD treatment and the disease, the own response of each species’ strains to the T2DM effects, or by the different levels of expression of skeletal growth modulators such as PTH and IGF-1, which have been associated with the bone resorption and/or bone formation processes (58, 59). This evidence concerns the gene PTH and type 2 diabetes mellitus.