According to the study from Reyes-García et al., the parathyroid hormone (PTH) can be linked to bone resorption in T2DM due to its positive association with the markers serum tartrate-resistant acid phosphatase-5b in T2DM patients, and serum terminal cross-linked telopeptide of type-I collagen (s-CTX) (45). This evidence concerns the gene ACP5 and type 2 diabetes mellitus.