PPARG and type 2 diabetes mellitus: The observed abnormality of increased PPARγ expression and elevated marrow adiposity in the femoral diaphyseal area has been confirmed by other studies (3, 22), using the DIO C57BL/6J mice model under HFD treatment and comparing to low-fat diet-fed mice (3), confirming the T2DM fracture healing impairment cocaused by the event of fate switch from osteoblasts to adipocytes.