Immunohistochemical stainings for OC and RUNX-2 were performed at days 3, 5, and 7 post-surgery, revealing a significant decrease in the levels of both biomarkers in T2DM mice, specifically at days 3 and 7 post-surgery for RUNX-2 and OC, respectively. This evidence concerns the gene BGLAP and type 2 diabetes mellitus.