Thus, the present results of this study, and namely the insufficient HSP response (Figure 2), contribute further evidence that the etiology of ALS is propagated by system-wide homeostatic instability that can be initiated by multiple factors, especially in long motoneurons, which are known to be more vulnerable to instability than other neuron types (Kim et al., 2016). Here, HSP90B2P is linked to amyotrophic lateral sclerosis.