Severe dermatitis induced by repeated DNFB-application under SPF condition in NC/Nga was alleviated partially in NC.h2b/nc and significantly in NC.h2b/b as shown by decreased epidermal expression levels of TSLP and serum levels of total IgE, TSLP, IL-18 and IL-33. The gene discussed is TSLP; the disease is dermatitis.