Having shown that EphB2 expression is elevated on HSCs during liver fibrosis and that it is required for TGF-β1 signaling and CCl4-induced hepatic fibrosis in mice, we next hypothesized that EphB2 deficiency could dampen the differentiation of HSCs into fibrogenic myofibroblasts. This evidence concerns the gene TGFB1 and Hepatic fibrosis.