To ascertain whether this observation is also relevant during liver fibrosis in non-infectious settings in mice, we determined the mRNA expression profile of EphB receptors and Ephrin-B ligands in two mouse models of hepatic fibrosis: chronic administration of the hepatotoxic chemical carbon tetrachloride (CCl4) and the MDR2-null mice fed a normal rodent laboratory diet to induce biliary fibrosis27. This evidence concerns the gene ABCB4 and Hepatic fibrosis.