Two patients (P05 and P06) with the highest fraction of positive PD-L1 cells in their tumor (P05: 99.5%, P06: 99.9%) also had the highest fraction of PD-L1 positive CTCs (P05: 47.4%, P06: 66.7%), with a significant part of CTCs having medium or high PD-L1 expression (P05: 26.3%, P06: 12.5%) and (P06: 4 of 24 in P06). This evidence concerns the gene CD274 and neoplasm.