Extrinsic factors also play an important role in triggering glucagon secretion, in particular, the signals from the sympathetic and parasympathetic branches of the autonomic nervous system4,5, which are activated by hypoglycemia-sensing neurons present in the extrapancreatic sites, such as the hepatoportal vein area6,7 and the central nervous system5,8,9. Here, GCG is linked to Hypoglycemia.