Using a mouse model of FOP in which a constitutively active mutant form of ALK2 (caALK2) is expressed upon injection of Adenovirus Cre (Ad.Cre) and cobra venom factor38, we found injection of 1D11 also significantly decreased HO progression (Fig. 5l, m). The gene discussed is HMOX1; the disease is fibrodysplasia ossificans progressiva.