SIRT5 and colorectal carcinoma: As summarized in Fig. 1h, after adjustment for age, gender, histological grade, and AJCC stage, multivariate Cox proportional hazards regression analysis confirmed that SIRT5 upregulation is independently associated with higher risk of mortality in patients with CRC, with an average follow-up of 5 years (hazard ratio = 3.06, 95% CI = 1.37–6.87, P = 0.007).