Consistently with an early in vitro study suggesting a role for the TRPM2 channel in Aβ42-induced neurotoxicity24, a recent study shows that genetic ablation of TRPM2 in the APP/PS-1 mice prevented neurotoxicity and age-related memory impairment32, supporting a causative relationship of the TRPM2 channel with AD, particularly Aβ-induced neurotoxicity and cognitive dysfunction. Here, APP is linked to Alzheimer disease.