(Fig. 1a).The qRT-PCR and western-blot analysis showed that the levels of messenger RNA (mRNA) and protein for mitophagic markers, including ATG5, ATG7, MAP1LC3B, PINK1, and SQSTM1, were evidently up-regulated in the livers of the BA patients related to the control subjects (Fig. 1b–d). This evidence concerns the gene SQSTM1 and breast angiosarcoma.