In conclusion, we demonstrated that miR-195 inhibits the growth of NSCLC cells by regulating cell cycle progression, apoptosis, and senescence, that miR-195 suppresses NSCLC, at least partially, through targeting CCND3 and BIRC5, and that dysregulation of the miR-195/BIRC5 axis may contribute to the progression of lung adenocarcinoma, establishing the relevance of levels of miR-195 and BIRC5 as prognostic factors and of the miR-195/BIRC5 axis as a therapeutic target for lung adenocarcinoma. Here, CCND3 is linked to non-small cell lung carcinoma.