UHRF1 and neoplasm: Given the evidences documented on the potential roles of UHRF1 in maintenance of genome integrity and DNA repair, we explored a possibility that high UHRF1 expression in retinoblastoma may contribute to protection against endogenous DNA damages and genotoxic drugs to promote the tumor cell survival and growth, and investigated the functions of UHRF1 in response to DNA damages induced by chemotherapeutic drugs in retinoblastoma cells.