For example, 14-3-3ζ was upregulated in HCC and can promote HCC invasion and metastasis through binding to AXL (activity of the receptor tyrosine kinase Axl)9 or through interacting with αB-crystallin mediated by TGF-β and ERK signaling pathways8. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.