RHBDF2 and myocardial infarction: However, during diastole we observed a significant increase in the end-diastolic volume (EDV) in iRhom2-deficient hearts compared with controls at day 21 after MI (WT, 2.01 ± 0.21 μl/g; iRhom2-deficient, 2.35 ±0.13 μl/g; n = 5 mice per group; mean ± SEM; P ≤ 0.05; Figure 5E), which was visualized by an expanded lumen adjacent to the scar of the ventricular wall (Figure 5, F and G).