Recently, the AMPLE (Abatacept versus Adalimumab Comparison in Biologic-Naïve RA Patients with Background Methotrexate) study, comparing abatacept with the TNF inhibitor adalimumab, provided conclusive evidence that abatacept leads to rapid control of signs and symptoms of inflammation in patients with RA [14]. Here, TNF is linked to rheumatoid arthritis.