In a recent study, MacDonald et al. [2] reported that the proportions of conventional Th17 cells in CD4+FoxP3− T cells and Th17-like Tregs in CD4+FoxP3+ T cells are comparable in the skin of 36 patients with SSc (average disease duration 5.7 ± 1.1 years for dcSSc and 5.7 ± 1.8 years for limited cutaneous systemic sclerosis) and 20 healthy control subjects. Here, CD4 is linked to systemic sclerosis.