Haplo insufficiency of FOXL2 function, resulting from mutations of the FOXL2 gene has been shown to cause the blepharophimosis–ptosis–epicanthus inversus syndrome (BPES), a genetic disorder characterized by eyelid and mild craniofacial abnormalities, associated with premature ovarian failure in a subset of affected women [2]. The gene discussed is FOXL2; the disease is primary ovarian failure.