MiR-20 [21], miR-29b [22], miR-93 [23–25], miR-126 [26–30], miR-190 [31], miR-195 [32], miR-200 [33, 34], miR-203 [35], miR-497 [36, 37], miR-503 [38] and miR-638 [39] have been experimentally shown to directly target the 3’UTR region of VEGF-A mRNA in different types of cancer and subsequently impairing the pro-angiogenesis signaling of VEGF/VEGFR-2 in endothelial cells. The gene discussed is VEGFA; the disease is cancer.