AKT1 and neoplasm: Apart from directly targeting VEGF, a handful of miRNAs regulate VEGF-dependent tumor angiogenesis by targeting VEGF inducers, such as HIF pathway (miR-22 [43], miR-107 [44], miR-519c [45], miR-145 [46]), PI3K/AKT pathway (miR-26a [47], miR-145 [48]), mTOR pathway (miR-18a [49], miR-128 [50], miR-145 [51], miR-218 [52]), IGF1R pathway (miR-126 [53], miR-181b [54], miR-148a [55], miR-152 [55]) and VEGF upstream transcription factors (STAT3: miR-874 [56], Bmi-1: miR-16 [57], E2F3: miR-34a [58], NF90: miR-590-5p [59]).