Before adjustment, the baseline variables of patient age, hospital volume, emergency transport, sepsis, cancer, pneumonia, pancreatitis, lung and abdominal trauma, hemodialysis, neurological dysfunction, shock, insulin, antithrombin III, recombinant human soluble thrombomodulin, platelet and red cell transfusions, albumin administration, immunoglobulin administration, and ICU transfer were significantly different between the high-dose and non-high-dose corticosteroid groups. The gene discussed is INS; the disease is Sepsis.