Next, we constructed multivariable Cox models of gender adjusted for clinical factors and pathologic features, but no significant differences in renal outcomes between male and female IgAN patients were observed after adjustments for age and hypertension in Model 1 (HR: 1.12, P = 0.584), after adding pathologic features (proportions of global glomerulosclerosis, degrees of S and T lesions) in Model 2 (HR: 0.95, P = 0.824), or after adding pathologic features and clinical parameters (albumin and proteinuria) in Model 3 (HR: 0.97, P = 0.876). This evidence concerns the gene ALB and glomerulosclerosis.