Interestingly, cAMP-responding element-binding (CREB) protein could bind to c-Ets1 to regulate ATP-dependent MUC5AC gene expression [6], and the protein interaction between Suppressor of Cytokine Signaling (SOCS) 3 and Non-POU domain-containing, octamer-binding protein (NonO) inhibited IL-1β-induced MUC8 gene expression, suggesting that intracelluar protien could act as a negative regulator to maintain homeostasis during airway inflammation [25]. This evidence concerns the gene NONO and inflammatory response.