Based on our data of circSMARCA5 modulation (Figure 5A) and according to Jumaa et al. and Jihua et al. [31,33], we hypothesize that circSMARCA5 downregulation in GBM biopsies, associated with upregulation of SRSF1 (Figure S5), may promote the skipping of exon 4 in SRSF3 pre-mRNA. The gene discussed is SRSF3; the disease is glioblastoma.