Unexpectedly, (mRNA) SRSF3 including exon 4 (SRSF3 Ex4) was also upregulated in GBM biopsies (Figure 5B) but, consistently with data obtained in U87MG cells overexpressing circSMARCA5, the SRSF3 Ex4/SRSF3 No Ex4 ratio positively correlated with the expression of circSMARCA5 in GBM biopsies (Figure 5C) (see Section 3). Here, SRSF3 is linked to glioblastoma.