For example, in the adipose tissue of Zip14-KO mice, hypertrophy together with enhanced proinflammatory signaling is observed through activation of nuclear factor-kappaB (NF-κB) and the Janus-activating kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway, and this might contribute to obesity-induced insulin resistance [62]. Here, STAT3 is linked to Insulin resistance.