Compared with the ALL group, levels of NF-κB, TNF-α, IL-1β, IL-4 and IL-6 mRNA and protein were significantly decreased, and IL-10 mRNA and protein expression was significantly increased in the ALI + COS group (Fig 3F–3L, P < 0.05). Here, NFKB1 is linked to acute lymphoblastic leukemia.