In contrast to those epigenetic marks in MCF-7 cell, other human cells (GM12878, H1-hESC, HSMM, HUVEC, K562, NHEK and NHLF) did not exhibit such strong H3K4me3 marks in the genomic regions, explaining why ESR1 could be involved in various fusion gene types only in breast carcinoma, but not in other human cell types (Figure 2). This evidence concerns the gene ESR1 and breast carcinoma.