Recently, Lind et al. developed a targeted proteomics chip including three circulating proteins (NT-pro-BNP, adrenomedullin, and eosinophil cationic protein) that could predict incident ischaemic stroke in two independent Swedish cohorts of adults aged over 70 years, independently of established cardiovascular risk factors and prevalent atrial fibrillation. The gene discussed is RNASE3; the disease is atrial fibrillation.