HSPA5 and myocardial infarction: Therefore, the major molecules GRP78 and CHOP of the ER stress pathway, as well as apoptosis-related Bcl2/Bax were selected to elaborate the mechanism of ER stress on OLE against acrolein-worsening MI in rats and the antagonism of HT against acrolein in cardiomyocytes H9c2 cells.