CCL2 and inflammatory response: In addition, we observed that treatment of infected CBA macrophages with PK11195 significantly reduced production of the macrophage attractant chemokine MCP-1; this finding is consistent with a report published by Bribes et al. (2003), which showed that treatment of MRL/1pr mice with PK11195 reduced the amount of inflammatory infiltrate in a mouse model of pulmonary inflammation.