While previous studies had explored the candidacy of selected variants at the CDC123 (Fogarty et al., 2014) and ADCY5 (Olsson et al., 2014; Hodson et al., 2014; van de Bunt et al., 2015) loci with respect to islet regulation and T2D predisposition, our integrative analysis of T2D GWAS and epigenetic data has enabled a detailed and comprehensive analysis that considers the regulatory impact of all variants at these loci across multiple islet samples. The gene discussed is ADCY5; the disease is type 2 diabetes mellitus.