However, an increased risk of breast cancer was observed in individuals who carry both the Leu198Leu genotype of GPX1 and Ala16Ala genotype of MnSOD which is in favor of a GPX1 and MnSOD interaction responsible of an increased risk of breast cancer development (Cox, Tamimi, & Hunter, 2006). This evidence concerns the gene GPX1 and breast carcinoma.