SLC5A2 and type 2 diabetes mellitus: To date, four SGLT2 inhibitors—canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin—have been approved for the treatment of T2DM in the United States, and the American Association of Clinical Endocrinologists (AACE) endorses the use of SGLT2 inhibitors as the first adjunctive oral AHA for combination therapy with metformin [8].