This analysis is strengthened by the use of ECHO-T2DM, which has demonstrated good model validity for established effects of AHAs on intermediate biomarkers such as glucose, body weight, BP, and renal function [34], but it does not yet account for the potential direct cardioprotective effects of SGLT2 inhibitors that have been reported recently [64, 66]. Here, SLC5A2 is linked to type 2 diabetes mellitus.