Similar observations in patients with established cardiovascular disease from the Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) and the CVD-REAL observational study suggest that cardioprotection is likely to be a class effect for SGLT2 inhibitors [66, 67]. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.