The expression of low-density lipoprotein receptor related protein 1 (LRP1), which mediates the efflux of Aβ from the brain to the periphery, is significantly reduced in the brain ECs of AD patients, whereas the expression of endothelial RAGE increases, promoting Aβ influx back into the CNS and favouring Aβ accumulation in the brain [83]. The gene discussed is LRP1; the disease is Alzheimer disease.