IL-6 and IL-10 were significantly increased in both the HCC and GBC groups, whereas IL-2, IL-6, IL-10, and TNF-α were significantly increased in the cholangiocellular carcinoma group, and IL-2, IL-6, IL-8, and TNF-α were significantly increased in the pancreatic cancer group. This evidence concerns the gene TNF and familial pancreatic carcinoma.