Because POSTN is abundant in the tumor stroma of MF and dermatofibrosarcoma protuberans (DFSP) (5, 9), and because substantial numbers of CD163+ TAMs have been detected in the POSTN-rich area in the lesional skin of skin tumors (5, 9), the production of MMP1 and MMP12 is prominent in the lesional skin of MF and DFSP. This evidence concerns the gene POSTN and skin neoplasm.