LTF and rheumatoid arthritis: Since some of the major autoantigens, such as lactoferrin (LTF) and citrilunated fibrinogen, in RA patients are also TLR agonists (17, 18), we propose that RA-related ICs might be able to drive the conversion of M2 macrophages into M1-like phenotype via synergistic signaling through TLRs and FcγRs.