For example, in melanoma, the upregulation of chemokine genes, such as Ccl2, Ccl3, Ccl4, Ccl5, Cxcl9, and Cxcl10, in the tumor microenvironment correlates with the influx of activated T cells into the tumor supporting the antitumor immune response (60). This evidence concerns the gene CCL3 and neoplasm.