IL1B and early-onset autosomal dominant Alzheimer disease: The induction of CNS expression of proinflammatory cytokines including IL-1 has been shown in animal models of acute brain injury (40–43), Alzheimer’s disease (44, 45), Parkinson’s disease (25), CNS autoimmunity (46), anxiety disorder (47–50), major depression (51–53), and autism (54).