A binary backward logistic regression model including age, gender, elevated hsCRP, active smoking, diabetes mellitus, and NIHSS >5 on admission revealed that a FVIII activity and VWF antigen level above the upper limit of the reference interval (168 and 160%, respectively) as measured immediately after lysis and 24 h after thrombolysis significantly and independently increase the risk of unfavorable functional outcomes at 90 days (Table 6). The gene discussed is VWF; the disease is diabetes mellitus.