Considered to the function of TLR2, TLR4, TLR7, TNF2, IL8, and IL18 (Briend et al., 2017; Sanguinete et al., 2017; Zhang et al., 2017), it was revealed that the immune defense would been inhibited for REV infection through salmonella infection, NOD-like receptor, Toll-like receptor and MAPK-AP1 pathways. This evidence concerns the gene TLR4 and Salmonella Infections.