While cerebrospinal fluid (CSF) and positron emission tomography (PET)-based biomarkers are available for AD pathology (β-amyloid and tau; Villemagne et al., 2017; Zetterberg, 2017) which may be associated with small vessel CeVD (Kester et al., 2014), these are relatively costly and invasive, and research efforts to uncover blood-based biomarkers are ongoing (Henriksen et al., 2014; Zetterberg, 2017). This evidence concerns the gene MAPT and Alzheimer disease.