SLC1A2 and amyotrophic lateral sclerosis: Given that astrocytic EAATs play a key role in protecting against microglial glutamate-induced neuronal death, it is possible that reduced expression of EAAT2 and glutamate excitotoxicity in ALS (Rothstein et al., 1995; Bristol and Rothstein, 1996; Lin et al., 1998) may be strongly influenced by lipid activity.