PLOD2 and neoplasm: Subsequent findings by our group showed that metastatic lung adenocarcinomas produce a stable type of collagen cross-link driven by high expression of LH2; LH2 depletion in tumor cells led to a reduction in tumor stiffness and metastatic activity and a change in the type, but not the total amount, of collagen cross-links as manifested by a decrease in hydroxylysine (Hyl) aldehyde-derived collagen cross-links (HLCCs) and a reciprocal increase in Lys aldehyde-derived collagen cross-links (LCCs)10.