Given that the HLCC-to-LCC ratio (Fig. 4f) and Hyl-to-collagen ratio (Fig. 4a) were higher in L230-transfected tumors than in controls, we conclude that L230 has both helical and telopeptidyl LH activities that result in a collagen cross-link switch in tumor stroma, which recapitulates LH2 properties10. This evidence concerns the gene PLOD2 and neoplasm.