IL6 and ischemia: There was a notable reduction in frequency of CD8+ IFNγ+ T cells in both groups following anti-IL-6, but the effect size was markedly greater in ischemic grafts (49.04 ± 0.52 vs. 106.74 ± 2.97 fold reduction in CD8+ IFNγ+ infiltration, control vs. ischemia, ***p < 0.001, respectively, n = 3/group) (Fig. 5D).