Furthermore, treatment with anti-IL-6 significantly decreased CD4+ and CD8+ T cell infiltration of ischemic grafts (anti-IL-6 treated ischemic grafts vs. untreated ischemic controls: 18.5 × 104 ± 0.1 × 104 vs. 27.2 × 104 ± 2.6 × 104, *p < 0.05 for CD4+ T cells and 1.41 × 104 ± 0.1 × 104 vs. 3.4 × 104 ± 0.2 × 104, ***p < 0.001 for CD8+ T cells, respectively, n = 3/group) (Fig. 5B: ischemia + anti-IL-6 and Fig. 2C: ischemia). Here, CD4 is linked to ischemia.