Although several studies have demonstrated that reducing myeloid cell accumulation by inhibition of the integrins α3β1 and αVβ3 decreases aberrant leukocyte infiltration in sepsis and protects from sepsis-related mortality48–50, neutralization of Mac-1 results in a strong inhibition of leukocyte mobilization, but also causes an accelerated bacterial sepsis with a higher mortality22–24,52. Here, ITGAM is linked to Sepsis.