GBM possesses so-called GICs, which share many NSC features such as expression of stem cell markers (i.e., Nestin, CD133), self-renewal, (i.e., continuous proliferation while maintaining an undifferentiated state), and multilineage differentiation capacity (i.e., ability to produce a heterogeneous population of differentiated cells)28,29. The gene discussed is PROM1; the disease is glioblastoma.