PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Clarifying the specific genetic polymorphisms [especially PNPLA3 risk alleles (Patatin-like phospholipase domain-containing protein 3)] associated with a lean NAFLD, as shown in the study of Argo et al., and elucidating the phenotype responsible for the risk of developing the disease is one additional step towards improving the prevention und prognosis of the condition [26].